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Article

Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development.

Developmental biology - 15 Dec 2004

Selever Jennifer, Liu Wei, Lu Mei-Fang, Behringer Richard R, Martin James F

Abstract excerpt

In the developing limb, Bmp4 is expressed in the apical ectodermal ridge (AER) and underlying mesoderm. Insight into the function of Bmp4 in limb development has been hampered by the early embryonic lethality of Bmp4 null embryos. We directly investigated Bmp4 using a conditional null allele of Bmp4 and the Prx1(cre) transgene to inactivate Bmp4 in limb bud mesoderm. The limb bud mesoderm of Prx1(cre);Bmp4...

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Source

Identifiers

PMID: 15581864
DOI: 10.1016/j.ydbio.2004.08.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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