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Article

Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.

Cell - 20 Aug 2004

Ahn Sohyun, Joyner Alexandra L

Abstract excerpt

In the vertebrate limb, the posteriorly located zone of polarizing activity (ZPA) regulates digit identity through the morphogen Sonic Hedgehog (Shh). By genetically marking Shh-responding cells in mice, we have addressed whether the cumulative influence of positive Shh signaling over time and space reflects a linear gradient of Shh responsiveness and whether Shh could play additional roles in limb patterning....

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Identifiers

PMID: 15315762
DOI: 10.1016/j.cell.2004.07.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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