Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.

Development (Cambridge, England) - 1 Nov 1999

Lettice L, Hecksher-Sørensen J, Hill R E

Abstract excerpt

Epithelial-mesenchymal interactions are essential for both limb outgrowth and pattern formation in the limb. Molecules capable of communication between these two tissues are known and include the signaling molecules SHH and FGF4, FGF8 and FGF10. Evidence suggests that the pattern and maintenance of expression of these genes are dependent on a number of factors including regulatory loops between genes expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Protein 4
Share to Ectoderm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor 10

Share to Fibroblast Growth Factor 8

Share to Fibroblast Growth Factors

Share to Hindlimb

Share to Limb Buds

Share to Polydactyly

Source

Identifiers

PMID: 10518490
DOI: 10.1242/dev.126.21.4729

Genes

FGF10
FGF4
FGF8
SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dominant hemimelia mutation uncouples epithelial-mesenchymal interactions and disrupts anterior mesenchyme formation in mouse hindlimbs.PMID 10518490Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

Dual Bmp-negative feedback loops modulate both AER and ZPA function to buffer and constrain postaxial digit numberSemantic proximity Read ↗

Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.Semantic proximity Read ↗

Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function.Semantic proximity Read ↗

Functions of FGF signalling from the apical ectodermal ridge in limb development.Semantic proximity Read ↗

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.Semantic proximity Read ↗

Normal limb development in conditional mutants of Fgf4.Semantic proximity Read ↗

Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.Semantic proximity Read ↗

FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.Semantic proximity Read ↗

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.Semantic proximity Read ↗

The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly.Semantic proximity Read ↗

The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.