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Article

Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth.

Development (Cambridge, England) - 1 May 2013

Sheth Rushikesh, Grégoire Damien, Dumouchel Annie, Scotti Martina, Pham Jessica My Trang, Nemec Stephen, Bastida Maria Félix, Ros Marian A, Kmita Marie

Abstract excerpt

Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior-posterior and proximal-distal specification initiates in early limb bud concomitantly with the proliferative expansion of limb cells. Previous studies have shown that limb bud growth initially relies on fibroblast growth factors (FGFs) produced in the apical ectodermal ridge...

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PMID: 23633510
DOI: 10.1242/dev.089409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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