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Article

Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.

PloS one - 1 Jan 2012

Choi Kyung-Suk, Lee Chanmi, Maatouk Danielle M, Harfe Brian D

Abstract excerpt

Outgrowth and patterning of the vertebrate limb requires a functional apical ectodermal ridge (AER). The AER is a thickening of ectodermal tissue located at the distal end of the limb bud. Loss of this structure, either through genetic or physical manipulations results in truncation of the limb. A number of genes, including Bmps, are expressed in the AER. Previously, it was shown that removal of the BMP receptor...

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Identifiers

PMID: 22662233
DOI: 10.1371/journal.pone.0037826
PMCID: PMC3360612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.PMID 22662233Read ↗

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Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.Semantic proximity Read ↗

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