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Article

Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits.

Cell reports - 7 Apr 2020

Tissières Virginie, Geier Florian, Kessler Barbara, Wolf Eckhard, Zeller Rolf, Lopez-Rios Javier

Abstract excerpt

Digit loss/reductions are evolutionary adaptations in cursorial mammals such as pigs. To gain mechanistic insight into these processes, we performed a comparative molecular analysis of limb development in mouse and pig embryos, which revealed a loss of anterior-posterior polarity during distal progression of pig limb bud development. These alterations in pig limb buds are paralleled by changes in the mesenchymal...

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Identifiers

PMID: 32268095
DOI: 10.1016/j.celrep.2020.03.054
PMCID: PMC7166081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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