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Article

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.

Mechanisms of development - 1 Jan 2001

Kraus P, Fraidenraich D, Loomis C A

Abstract excerpt

Patterning of the limb is coordinated by the complex interplay of three signaling regions: the apical ectodermal ridge (AER), the zone of polarizing activity (ZPA), and the non-ridge limb ectoderm. Complex feedback loops exist between Shh in the ZPA, Bmps and their antagonists in the adjacent mesenchyme, Wnt7a in the dorsal ectoderm and Fgfs in the AER. In contrast to the previously reported complete absence of...

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PMID: 11118883
DOI: 10.1016/s0925-4773(00)00492-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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