Back to search

Article

A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatus

2021-03-29

Abstract excerpt

The InterFeron-Induced TransMembrane proteins (IFITMs) are broad viral inhibitors that protect cells by preventing viral-to-cellular membrane fusion and they belong to the dispanin/CD225 family that includes vesicle trafficking regulators and proteins of unknown functions into four subfamilies (A-D). In this study, we uncover a novel domain that regulates the egress of IFITM3 from the Golgi and that is required to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6cab5056-0617-52e5-872c-7921e42b8550
DOI
10.1101/2021.03.29.437470
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A novel domain within the CIL regulates egress of IFITM3 from the Golgi and prevents its deleterious accumulation in this apparatusDOI 10.1101/2021.03.29.437470
Homology-guided identification of a conserved motif linking the antiviral functions of IFITM3 to its oligomeric stateSemantic proximity
SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusionSemantic proximity
BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus ReplicationSemantic proximity
A sorting signal suppresses IFITM1 restriction of viral entry.Semantic proximity
The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human MembersSemantic proximity
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunitySemantic proximity
Traffic jams II: an update of diseases of intracellular transport.Semantic proximity
GARP Complex in Golgi Physiology.Semantic proximity
Stairway to the Golgi: Two paths VPS13B can go by.Semantic proximity
YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING TraffickingSemantic proximity
Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2Semantic proximity
Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.Semantic proximity
Select a neighboring publication to make it the new centre.