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Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into Virions.

Biomolecules - 18 Mar 2026

Verma Smita, Prikryl David, Marin Mariana, Markosyan Ruben M, Cimarelli Andrea, Melikyan Gregory B

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral factors that restrict the entry of many enveloped viruses, including HIV-1, by modifying host membrane properties and trapping fusion at the hemifusion stage. Beyond blocking entry in target cells, IFITMs also reduce the infectivity of virions produced from IFITM-expressing cells, a phenomenon termed "negative imprinting". Conserved...

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Antigens, Differentiation
Dogs
HEK293 Cells
HIV-1
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Virus Internalization

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Open in PubMed Open full text

Identifiers

PMID: 41897394
DOI: 10.3390/biom16030459
PMCID: PMC13023901

Genes

IFITM3
IFITM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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