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Article

SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusion

2024-08-08

Abstract excerpt

The CD225/Dispanins superfamily consists of membrane proteins that regulate vesicular transport and membrane fusion events driving neurotransmission, glucose transport, and antiviral immunity. However, how the CD225 domain controls membrane trafficking was unknown. We reveal that the CD225 domain contains a SNARE-like motif that enables interaction with cellular SNARE fusogens. Proline rich transmembrane protein 2...

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Identifiers and source

Literature Corpus work
026bde99-e0b1-545c-9692-fc99480b8f10
DOI
10.1101/2024.08.07.607021
Open publication

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SNARE mimicry by the CD225 domain of IFITM3 enables regulation of homotypic late endosome fusionDOI 10.1101/2024.08.07.607021
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