Back to search

Article

Opposing roles of endosomal innate immunity proteins IFITM3 and TLR7 in human metapneumovirus infection

2018-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Human metapneumovirus (hMPV) utilizes a bifurcated cellular entry strategy, fusing either with the plasma membrane or, after endocytosis, with the endosome membrane. Whether cellular factors restrict or enhance either entry pathway is largely unknown. We found that the interferon-induced transmembrane protein 3 (IFITM3) inhibits hMPV infection to an extent similar to endocytosis-inhibiting drugs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7b69a462-7393-5a90-bfb8-e8a97ae26787
DOI
10.1101/290957
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Opposing roles of endosomal innate immunity proteins IFITM3 and TLR7 in human metapneumovirus infectionDOI 10.1101/290957
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic EntrySemantic proximity
Opposing activities of IFITM proteins in SARS-CoV-2 infectionSemantic proximity
Opposing activities of IFITM proteins in SARS-CoV-2 infection.Semantic proximity
IFITM-Family Proteins: The Cell's First Line of Antiviral DefenseSemantic proximity
IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunitySemantic proximity
More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteinsSemantic proximity
A specific anti-IFITM2 antibody bars the way to SARS-CoV-2 entry into host cellsSemantic proximity
IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral InfectionsSemantic proximity
Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infectionSemantic proximity
A sorting signal suppresses IFITM1 restriction of viral entry.Semantic proximity
Current Progress on Host Antiviral Factor IFITMsSemantic proximity
IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infectionSemantic proximity
Select a neighboring publication to make it the new centre.