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Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into Virions

2026-02-13

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) are broad-spectrum antiviral factors that restrict the entry of many enveloped viruses, including HIV-1, by modifying host membrane properties and trapping fusion at the hemifusion stage. Beyond blocking entry in target cells, IFITMs also reduce the infectivity of virions produced from IFITM-expressing cells, a phenomenon termed “negative imprinting”. Conserved mo...

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Literature Corpus work
83d64721-2ac5-5dd5-bcc4-9cd98e5a45ea
DOI
10.20944/preprints202602.1090.v1
Open publication

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Divergent HIV-1 Restriction Phenotypes of IFITMs Expressed in Target Cells and Incorporated into VirionsDOI 10.20944/preprints202602.1090.v1
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