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Article

T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences.

eLife - 21 Jul 2017

Madi Asaf, Poran Asaf, Shifrut Eric, Reich-Zeliger Shlomit, Greenstein Erez, Zaretsky Irena, Arnon Tomer, Laethem Francois Van, Singer Alfred, Lu Jinghua, Sun Peter D, Cohen Irun R, Friedman Nir

Abstract excerpt

Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function. However, the level of sequence similarity of TCR repertoires within and between species has not been characterized. Using network analysis of high-throughput TCR sequencing data, we found that abundant CDR3-TCRβ sequences were clustered within networks generated by sequence similarity. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 28731407
DOI: 10.7554/eLife.22057
PMCID: PMC5553937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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