Article

Tissue determinants of the human T cell receptor repertoire.

2024-08-19

Abstract excerpt

98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors' autologous blood and tonsils and sought to answer key questions about T cell receptor biology previously unanswerable by smaller-scale experiments. We identified distinct clonal expansions and distributions in blood compared to tonsils, with surpr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54798d86-7f0e-55a8-87d6-9bf79b4dd753
DOI: 10.1101/2024.08.17.608295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue determinants of the human T cell receptor repertoire.DOI 10.1101/2024.08.17.608295Read

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture in humansSemantic proximity Read

T-Cell Receptor Repertoire Sequencing and Its Applications: Focus on Infectious Diseases and CancerSemantic proximity Read

High-resolution single-cell atlas of the human B cell compartment and immune microenvironment across tissuesSemantic proximity Read

Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypesSemantic proximity Read

Single-Cell Analysis Reveals Tissue-Specific T Cell Adaptation and Clonal Distribution Across the Human Gut-Liver-Blood AxisSemantic proximity Read

High Frequency of Shared Clonotypes in Human T Cell Receptor RepertoiresSemantic proximity Read

The human T‐cell receptor repertoire in health and disease and potential for omics integrationSemantic proximity Read

Human MAIT cells show clonal diversity but transcriptional and functional homogeneitySemantic proximity Read

Spatial transcriptomics of T and B cell receptors uncovers lymphocyte clonal dynamics in human tissueSemantic proximity Read

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes.Semantic proximity Read

Single-cell transcriptome profiling of an adult human cell atlas of 15 major organsSemantic proximity Read

High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities.Semantic proximity Read