Article

Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes

2025-06-03

Abstract excerpt

Single-cell techniques allow concurrent study of gene activity and T cell receptor (TCR) sequences, identifying connections between TCR structure and cell traits. Expanding on our CoNGA software, we present a “metaCoNGA” analysis of 6 million T cells from 91 diverse studies, mapping TCR sequence similarity across tissues and diseases. This approach exposes shared TCR features within specific T cell subsets, includ...

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Literature Corpus work: 929b6383-2803-531b-8887-10061f92159b
DOI: 10.1101/2025.05.31.657155

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