Characterization of sequence determinants of enhancer function using natural genetic variation.

Abstract excerpt

Sequence variation in enhancers that control cell-type-specific gene transcription contributes significantly to phenotypic variation within human populations. However, it remains difficult to predict precisely the effect of any given sequence variant on enhancer function due to the complexity of DNA sequence motifs that determine transcription factor (TF) binding to enhancers in their native genomic context....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Enhancer Elements, Genetic
• Share to Genetic Variation