Article
Super-enhancers in the control of cell identity and disease.
Cell - 7 Nov 2013
Hnisz Denes, Abraham Brian J, Lee Tong Ihn, Lau Ashley, Saint-André Violaine, Sigova Alla A, Hoke Heather A, Young Richard A
Abstract excerpt
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of transcription factors,...
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