Article

Characterization of sequence determinants of enhancer function using natural genetic variation

2021-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Sequence variation in enhancers, a class of cis-regulatory elements that control cell type-specific gene transcription, contributes significantly to phenotypic variation within human populations. Enhancers are short DNA sequences (∼200 bp) composed of multiple binding sites (4-10 bp) for transcription factors (TFs). The transcriptional regulatory activity of an enhancer is encoded by the type, n...

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Literature Corpus work: 889dbbf2-82d5-50e2-818a-d98720fe805f
DOI: 10.1101/2021.12.17.473050

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