Article

Essential genes are dominantly activated by single transcription factors

2026-04-30

Abstract excerpt

Cell viability depends on the precise expression of essential genes, which are controlled by CpG-island (CGI) promoters densely bound by transcription factors (TFs). This has led to the prevailing model that TFs cooperate to ensure ubiquitous expression. Here, using rapid and reversible single and combinatorial degradation in murine stem cells, we systematically dissect the regulatory interactions between five key...

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Literature Corpus work: 60003a33-4e2f-5c2e-8b77-4ae1d4abddc9
DOI: 10.64898/2026.04.27.721063

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