Article

Transcriptional profile of ribosome-associated quality control components and their associated phenotypes in mammalian cells

2023-02-07

Abstract excerpt

During protein synthesis, organisms detect translation defects that induce ribosome stalling and result in protein aggregation. The Ribosome-associated Quality Control (RQC) complex, comprising TCF25, LTN1, and NEMF, is responsible for identifying incomplete protein products from unproductive translation events, targeting them for degradation. Though RQC disruption causes adverse effects on vertebrate neurons, dat...

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Literature Corpus work: 07a6acef-0f76-5a37-a661-449998f9c953
DOI: 10.1101/2023.02.06.527332

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