Article

Counter-regulation of RNA stability by UPF1 and TDP43

2024-02-04

Abstract excerpt

RNA quality control is crucial for proper regulation of gene expression. Disruption of nonsense mediated mRNA decay (NMD), the primary RNA decay pathway responsible for the degradation of transcripts containing premature termination codons (PTCs), can disrupt development and lead to multiple diseases in humans and other animals. Similarly, therapies targeting NMD may have applications in hematological, neoplastic...

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Literature Corpus work: e32d601a-a0ea-5e82-88c8-8572016200c7
DOI: 10.1101/2024.01.31.578310

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