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Article

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits.

The Journal of biological chemistry - 3 Jun 2016

Defenouillère Quentin, Zhang Elodie, Namane Abdelkader, Mouaikel John, Jacquier Alain, Fromont-Racine Micheline

Abstract excerpt

Protein homeostasis is maintained by quality control mechanisms that detect and eliminate deficient translation products. Cytosolic defective proteins can arise from translation of aberrant mRNAs lacking a termination codon (NonStop) or containing a sequence that blocks translation elongation (No-Go), which results in translational arrest. Stalled ribosomes are dissociated, aberrant mRNAs are degraded by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27129255
DOI: 10.1074/jbc.M116.722264
PMCID: PMC4933273

Genes

CAT

Provenance

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