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Article

Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

22 Apr 2021

Abstract excerpt

Translation-dependent quality control pathways such as no-go decay (NGD), non-stop decay (NSD), and nonsense-mediated decay (NMD) govern protein synthesis and proteostasis by resolving non-translating ribosomes and preventing the production of potentially toxic peptides derived from faulty and aberrant mRNAs. However, how translation is altered and the in vivo defects that arise in the absence of these pathways...

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PMID: 33899734
DOI: 10.7554/elife.66904

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