Article

ZNF598 responds to mitochondrial stress to abort stalled translation on mitochondrial outer membrane and maintain tissue homeostasis

2022-02-04

Abstract excerpt

Translational control exerts immediate effect on the composition, abundance, and integrity of the proteome. Ribosome-associated quality control (RQC) handles ribosomes stalled at the elongation and termination steps of translation, with ZNF598 in mammals and Hel2 in yeast serving as key sensors of translation stalling and coordinators of downstream resolution of collided ribosomes, termination of stalled translati...

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Literature Corpus work: c39baf48-a3f4-57f9-91f0-1f9545e4a40e
DOI: 10.1101/2022.02.04.479092

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