Article

Protein products of non-stop mRNA disrupt nucleolar homeostasis

2019-11-22

Abstract excerpt

<h4>Summary</h4> Mutations that cause ribosome stalling or impair the cell’s protective response to stalling have been demonstrated to cause neurodegeneration, yet the mechanisms underlying these pathologies remain poorly understood. Here we investigated the fate of defective proteins translated from stall-inducing, nonstop mRNA that escape ubiquitylation by the Ribosome-associated Quality Control (RQC) E3 ligase...

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Literature Corpus work: 3a5eb78f-5e0a-5ab5-b79b-1d56c1b4330d
DOI: 10.1101/851741

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