Article

Sex-differentiated hormonal microenvironments recapitulate in vivo liver metabolism in human iPSC-derived organoids

2026-05-12

Abstract excerpt

Bioengineers strive to recreate in vivo microenvironments in vitro to reduce our use of animal models and provide insights into human biology. While liver models show promise, sex differences in liver biology remain largely neglected in preclinical studies. Despite the 2014 EU mandate for the inclusion of women in clinical trials, decoupling of research data by sex is historically rare, with only 11% of papers d...

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Literature Corpus work: 078790e2-3eb7-58d7-bbd5-af0c2c245a90
DOI: 10.64898/2026.05.09.723948

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