Article

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids

2023-12-04

Abstract excerpt

1. <h4>Objective</h4> Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by introducing a high-throughput, microfluidic liver-on-a-chip system, termed as “Curio Barrier Liver Chips,” seeded with human liver organoids to enable metabolic and phenotypic morphologic characterization. <h4>Methods</h4> Curio...

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Literature Corpus work: 5b1cf4cf-2694-567d-8026-ed6820da05fd
DOI: 10.1101/2023.12.01.569575

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