Article

MASLD-Induced Liver Micro-Organoids Mimics Clinical Observations of Impaired Vitamin D Synthesis

2024-12-31

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global health concern associated with various metabolic disorders and a high prevalence of vitamin D deficiency. Current animal models face limitations in accurately mimicking human metabolic pathways and are constrained by ethical considerations. This study aimed to develop an in vitro MASLD-induced liver micro-organoid model to investigate the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 32d11484-9053-55dc-9e0e-36365306094c
DOI: 10.20944/preprints202412.2546.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MASLD-Induced Liver Micro-Organoids Mimics Clinical Observations of Impaired Vitamin D SynthesisDOI 10.20944/preprints202412.2546.v1Read

Liver organoids: established tools for disease modeling and drug developmentSemantic proximity Read

Exploring the Multifaceted Landscape of MASLD: A Comprehensive Synthesis of Recent Studies, from Pathophysiology to Organoids and BeyondSemantic proximity Read

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functionsSemantic proximity Read

Single cell transcriptomic landscapes of human liver organoids stratify models of non-alcoholic fatty liver diseaseSemantic proximity Read

Metabolic Rewiring in MASLD: From Disease Mechanisms to Precision MedicineSemantic proximity Read

Translating Patient‑Specific Liver Organoid Multi‑Omics into Precision Diagnostics and Risk Stratification for Herb‑Induced Liver Injury: A Systematic ReviewSemantic proximity Read

Unraveling MASLD Through the Use of Omics TechnologiesSemantic proximity Read

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.Semantic proximity Read

Duodenal organoids from metabolic dysfunction-associated steatohepatitis patients exhibit altered digestive homeostasisSemantic proximity Read

High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived OrganoidsSemantic proximity Read

Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammationSemantic proximity Read

Integrated Spheroid-to-Population Framework for Evaluating PFHpA-Associated Metabolic Dysfunction and Steatotic Liver DiseaseSemantic proximity Read