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Article

Sex-dependent dynamics of metabolism in primary mouse hepatocytes

9 Jul 2021

Abstract excerpt

The liver is one of the most sexually dimorphic organs. The hepatic metabolic pathways that are subject to sexual dimorphism include xenobiotic, amino acid and lipid metabolism. Non-alcoholic fatty liver disease and hepatocellular carcinoma are among diseases with sex-dependent prevalence, progression and outcome. Although male and female livers differ in their abilities to metabolize foreign compounds, including...

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PMID: 34241659
DOI: 10.1007/s00204-021-03118-9

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