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Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue

11 Mar 2025

Abstract excerpt

The increase in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MASH) is a worldwide healthcare challenge. Heterogeneity between men and women in the prevalence and mechanisms of MASLD and MASH is related to differential sex hormone signalling within the liver, and declining hormone levels during aging. In this study we used...

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PMID: 40069876
DOI: 10.1186/s13287-025-04238-0

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