Article

Single-cell metabolic profiling reveals subgroups of primary human hepatocytes showing heterogeneous responses to drug challenge

2022-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes (PHHs) are the gold standard model for the assessment of drug efficacy, safety and toxicity in the early phases of drug development. Recent advances in single-cell genomics have shown liver zonation and ploidy as main drivers of cellular heterogeneity. However, little is known about the impact of hep...

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Literature Corpus work: feb50d88-d0e5-57e4-9d6d-333a49392103
DOI: 10.1101/2022.06.08.495252

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