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Article

Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human Liver

1 Jan 2012

Abstract excerpt

Human sex differences in the gene expression of drug metabolizing enzymes and transporters (DMETs) introduce differences in drug absorption, distribution, metabolism and excretion, possibly affecting drug efficacy and adverse reactions. However, existing studies aimed at identifying dimorphic expression differences of DMET genes are limited by sample size and the number of genes profiled. Focusing on a list of...

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PMID: 29177108
DOI: 10.4172/2157-7609.1000119

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