Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

doi:10.1016/j.jhep.2014.10.016

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Article

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.

Journal of hepatology - 1 Mar 2015

Baxter Melissa, Withey Sarah, Harrison Sean, Segeritz Charis-Patricia, Zhang Fang, Atkinson-Dell Rebecca, Rowe Cliff, Gerrard Dave T, Sison-Young Rowena, Jenkins Roz, Henry Joanne, Berry Andrew A, Mohamet Lisa, Best Marie, Fenwick Stephen W, Malik Hassan, Kitteringham Neil R, Goldring Chris E, Piper Hanley Karen, Vallier Ludovic, Hanley Neil A

Abstract excerpt

BACKGROUND & AIMS: Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear and compounded by comparison to potentially deteriorated adult hepatocytes. Therefore, we generated HLCs from multiple...

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Identifiers

PMID: 25457200
DOI: 10.1016/j.jhep.2014.10.016
PMCID: PMC4334496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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