Metabolic modeling of sex-specific tissue predicts mechanisms of differences in toxicological responses

Abstract excerpt

Male subjects in animal and human studies are disproportionately used for toxicological testing. This discrepancy is evidenced in clinical medicine where females are more likely than males to experience liver-related adverse events in response to xenobiotics. While previous work has shown gene expression differences between the sexes, there is a lack of systems-level approaches to understand the direct clinical im...

Topics

Open a Topic to create a Post that cites this publication.

• Cholesterol and Lipid Metabolism
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Hormonal Regulation and Hypertension
• Lipid metabolism and biosynthesis
• Liver Disease Diagnosis and Treatment
• Metabolomics and Mass Spectrometry Studies
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

4cd12d16-d732-5dd3-a922-7363b7d3d76d

DOI

10.1101/2023.02.07.527430