Article

Inference of clonal hematopoiesis using the collective behaviour of DNA methylation states

2025-11-18

Abstract excerpt

Clonal expansion occurs when descendants of a single progenitor cell come to dominate a tissue. We show that this process generates a predictable collective behaviour in DNA methylation landscapes: at CpG sites that faithfully transmit their allelic methylation status across cell divisions, methylation proportions shift toward discrete values (0%, 50%, or 100%) as clones expand. We demonstrate this phenomenon in c...

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Literature Corpus work: 07509d87-ef4f-5755-aea4-d16a7c2f7e68
DOI: 10.1101/2025.11.18.689122

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