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Article

Cardelino: computational integration of somatic clonal substructure and single-cell transcriptomes.

Nature methods - 1 Apr 2020

McCarthy Davis J, Rostom Raghd, Huang Yuanhua, Kunz Daniel J, Danecek Petr, Bonder Marc Jan, Hagai Tzachi, Lyu Ruqian, Wang Wenyi, Gaffney Daniel J, Simons Benjamin D, Stegle Oliver, Teichmann Sarah A

Abstract excerpt

Bulk and single-cell DNA sequencing has enabled reconstructing clonal substructures of somatic tissues from frequency and cooccurrence patterns of somatic variants. However, approaches to characterize phenotypic variations between clones are not established. Here we present cardelino (https://github.com/single-cell-genetics/cardelino), a computational method for inferring the clonal tree configuration and the...

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PMID: 32203388
DOI: 10.1038/s41592-020-0766-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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