Article
Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate.
Nature aging - 1 Aug 2024
Mack Taralynn M, Raddatz Michael A, Pershad Yash, Nachun Daniel C, Taylor Kent D, Guo Xiuqing, Shuldiner Alan R, O'Connell Jeffrey R, Kenny Eimear E, Loos Ruth J F, Redline Susan, Cade Brian E, Psaty Bruce M, Bis Joshua C, Brody Jennifer A, Silverman Edwin K, Yun Jeong H, Cho Michael H, DeMeo Dawn L, Levy Daniel, Johnson Andrew D, Mathias Rasika A, Yanek Lisa R, Heckbert Susan R, Smith Nicholas L, Wiggins Kerri L, Raffield Laura M, Carson April P, Rotter Jerome I, Rich Stephen S, Manichaikul Ani W, Gu C Charles, Chen Yii-Der Ida, Lee Wen-Jane, Shoemaker M Benjamin, Roden Dan M, Kooperberg Charles, Auer Paul L, Desai Pinkal, Blackwell Thomas W, Smith Albert V, Reiner Alexander P, Jaiswal Siddhartha, Weinstock Joshua S, Bick Alexander G
Abstract excerpt
Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only correlates with age but also confers increased risk of morbidity and mortality. Here, we leverage genetically predicted traits to identify factors that determine CHIP clonal expansion rate. We used the passenger-approximated clonal...
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