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Article

Genetics of smoking and risk of clonal hematopoiesis.

Scientific reports - 4 May 2022

Levin Michael G, Nakao Tetsushi, Zekavat Seyedeh M, Koyama Satoshi, Bick Alexander G, Niroula Abhishek, Ebert Benjamin, Damrauer Scott M, Natarajan Pradeep

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) represent two forms of clonal hematopoiesis where clones bearing expanded somatic mutations have been linked to both oncologic and non-oncologic clinical outcomes including atherosclerosis and all-cause mortality. Epidemiologic studies have highlighted smoking as an important driver of somatic mutations across...

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Identifiers

PMID: 35508625
DOI: 10.1038/s41598-022-09604-z
PMCID: PMC9068754

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