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Article

Dynamic evolution of clonal epialleles revealed by methclone.

Genome biology - 27 Sept 2014

Li Sheng, Garrett-Bakelman Francine, Perl Alexander E, Luger Selina M, Zhang Chao, To Bik L, Lewis Ian D, Brown Anna L, D'Andrea Richard J, Ross M Elizabeth, Levine Ross, Carroll Martin, Melnick Ari, Mason Christopher E

Abstract excerpt

We describe methclone, a novel method to identify epigenetic loci that harbor large changes in the clonality of their epialleles (epigenetic alleles). Methclone efficiently analyzes genome-wide DNA methylation sequencing data. We quantify the changes using a composition entropy difference calcula...

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Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Molecular Sequence Annotation

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Identifiers

PMID: 25260792
DOI: 10.1186/s13059-014-0472-5
PMCID: PMC4242486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25260792-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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