Article

Experimental Kinetic Mechanism of P53 Condensation-Amyloid Aggregation

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> The tumor suppressor p53 modulates the transcription of a variety of genes constituting a protective barrier against anomalous cellular proliferation. High frequency “hot-spot” mutations result in loss-of-function by the formation of amyloid-like aggregates that correlate with cancerous progression. We show that full-length p53 undergoes spontaneous homotypic condensation at sub-micromolar conce...

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Literature Corpus work: 06f40327-608c-530d-81d7-88cd058c5684
DOI: 10.1101/2025.02.03.635948

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