Article

The physics of liquid-to-solid transitions in multi-domain protein condensates

2021-11-18

Abstract excerpt

Many RNA-binding proteins (RBPs) that assemble into membraneless organelles, have a common architecture including disordered prion-like domain (PLD) and folded RNA-binding domain (RBD). An enrichment of PLD within the condensed phase gives rise to formation, on longer time scales, amyloid-like fibrils (aging). In this study, we employ coarse-grained Langevin dynamics simulations to explore the physical basis for t...

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Literature Corpus work: a840ed7c-97f5-5632-9657-b72d83073678
DOI: 10.1101/2021.11.15.468745

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