Article
The chameleonic behavior of p53 in health and disease: the transition from a client to an aberrant condensate scaffold in cancer
9 Nov 2022
Abstract excerpt
In 1972, the Weber statement, "The multiplicity of interactions and the variety of effects that follow from them show that multimer proteins are unlikely to be limited to a minimal number of allowed conformations," first addressed the dynamic nature of proteins. This idea serves as a foundation for understanding why several macromolecules, such as p53, exhibit the properties of a molecular chameleon. Functionally...
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