Article

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein

2024-09-08

Abstract excerpt

Biomolecular condensates formed via phase separation of proteins and nucleic acids are crucial for the spatiotemporal regulation of a diverse array of essential cellular functions and the maintenance of cellular homeostasis. However, aberrant liquid-to-solid phase transitions of such condensates are associated with several fatal human diseases. Such dynamic membraneless compartments can contain a range of molecula...

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Literature Corpus work: 67977b4e-8096-511b-8c82-d0c7899473e9
DOI: 10.1101/2024.09.05.611572

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Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion proteinDOI 10.1101/2024.09.05.611572Read

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