Article
Phase Separation and Prion-Like Aggregation of p53 Family Tumor Suppressors: From Protein Evolution to Cancer Treatment.
Journal of neurochemistry - 1 Apr 2025
Silva Jerson L, de Andrade Guilherme C, Petronilho Elaine C, de Sousa Gileno Dos S, Mota Michelle F, Quarti Julia, Guedes-da-Silva Francisca H, Ferretti Giulia D S, Rangel Luciana P, Vieira Tuane C R G, Marques Mayra A, de Oliveira Guilherme A P
Abstract excerpt
Biomolecular condensates, formed through phase separation (PS), are essential in various physiological processes, but they can also transition into amyloid-like structures, contributing to diseases like cancer and neurodegenerative disorders. This review centers on the tumor suppressor protein p53 and its paralogs, p63 and p73, which play significant roles in cancer biology. Mutations in the TP53 gene, present in...
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