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Article

Nucleo-cytoplasmic environment modulates spatiotemporal p53 phase separation.

Science advances - 13 Dec 2024

Datta Debalina, Navalkar Ambuja, Sakunthala Arunima, Paul Ajoy, Patel Komal, Masurkar Shalaka, Gadhe Laxmikant, Manna Shouvik, Bhattacharyya Arpita, Sengupta Shinjinee, Poudyal Manisha, Devi Jyoti, Sawner Ajay Singh, Kadu Pradeep, Shaw Ranjit, Pandey Satyaprakash, Mukherjee Semanti, Gahlot Nitisha, Sengupta Kundan, Maji Samir K

Abstract excerpt

Liquid-liquid phase separation of various transcription factors into biomolecular condensates plays an essential role in gene regulation. Here, using cellular models and in vitro studies, we show the spatiotemporal formation and material properties of p53 condensates that might dictate its function. In particular, p53 forms liquid-like condensates in the nucleus of cells, which can bind to DNA and perform...

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Identifiers

PMID: 39661689
DOI: 10.1126/sciadv.ads0427
PMCID: PMC11633762

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