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Article

Divergent effects of pathological α-synuclein truncations and mutations on phase separation.

Nature communications - 25 Jun 2026

Ray Soumik, Kunka Antonin, Hertel Sophie, Chiodaroli Cecilia, Schott Katharina, Farzadfard Azad, Mojtic Kristina, Klausen Louise Kjær, Marlet Frederik Ravnkilde, Galvagnion Céline, Buell Alexander K

Abstract excerpt

Phase separated condensates of α-synuclein (α-Syn) accelerate amyloid fibril formation, a process implicated in Parkinson's disease pathogenesis. Yet, the precise effects of pathologically relevant α-Syn sequence modifications on this process remain unclear. Here, we show that sequence truncations exert the strongest influence on condensate thermodynamics, material properties, and amyloid aggregation, whereas...

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Identifiers

PMID: 42350393
DOI: 10.1038/s41467-026-74627-3
PMCID: PMC13448243

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