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Article

Liquid-like droplet formation by tumor suppressor p53 induced by multivalent electrostatic interactions between two disordered domains.

Scientific reports - 17 Jan 2020

Kamagata Kiyoto, Kanbayashi Saori, Honda Masaya, Itoh Yuji, Takahashi Hiroto, Kameda Tomoshi, Nagatsugi Fumi, Takahashi Satoshi

Abstract excerpt

Early in vivo studies demonstrated the involvement of a tumor-suppressing transcription factor, p53, into cellular droplets such as Cajal and promyelocytic leukemia protein bodies, suggesting that the liquid-liquid phase separation (LLPS) might be involved in the cellular functions of p53. To examine this possibility, we conducted extensive investigations on the droplet formation of p53 in vitro. First, p53...

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Identifiers

PMID: 31953488
DOI: 10.1038/s41598-020-57521-w
PMCID: PMC6969132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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