Article

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensation

2025-02-02

Abstract excerpt

Circadian timekeeping is orchestrated by multiple clock proteins, but mechanistic understanding is limited. AlphaFold predicts novel interactions between two helical domains of the Drosophila PERIOD (PER) protein and its major kinase Doubletime (DBT). These PER domains, SYQ and LT, are conserved with mammals and are predicted to interact identically with the DBT ortholog casein kinase 1 (CK1). SYQ and LT mutation...

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Literature Corpus work: 06ec9562-7e5f-5157-af05-0793c18e0d1f
DOI: 10.1101/2025.02.01.636007

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