Article
The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.
Genes & development - 1 Jul 2008
Chiu Joanna C, Vanselow Jens T, Kramer Achim, Edery Isaac
Abstract excerpt
A common feature of animal circadian clocks is the progressive phosphorylation of PERIOD (PER) proteins, which is highly dependent on casein kinase Idelta/epsilon (CKIdelta/epsilon; termed DOUBLETIME [DBT] in Drosophila) and ultimately leads to the rapid degradation of hyperphosphorylated isoforms via a mechanism involving the F-box protein, beta-TrCP (SLIMB in Drosophila). Here we use the Drosophila melanogaster...
Topics
- Animals
- Binding Sites
- Casein Kinase 1 epsilon
- Cell Cycle Proteins
- Cells, Cultured
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Mass Spectrometry
- Mutation
- Nuclear Proteins