Article
Activating PER repressor through a DBT-directed phosphorylation switch.
PLoS biology - 29 Jul 2008
Kivimäe Saul, Saez Lino, Young Michael W
Abstract excerpt
Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of certain proteins that constitute the biological clock. This study examines the role of the protein kinase Doubletime (DBT), a Drosophila orth...
Topics
- Animals
- Blotting, Northern
- Blotting, Western
- Casein Kinase 1 epsilon
- Cell Line
- Circadian Rhythm
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression
- Mutation
- Nuclear Proteins
- Period Circadian Proteins
- Phosphorylation
- Recombinant Proteins
- Spodoptera