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Article

Activating PER repressor through a DBT-directed phosphorylation switch.

PLoS biology - 29 Jul 2008

Kivimäe Saul, Saez Lino, Young Michael W

Abstract excerpt

Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of certain proteins that constitute the biological clock. This study examines the role of the protein kinase Doubletime (DBT), a Drosophila ortholog of human casein kinase I (CKI)epsilon/delta. An enzymatically active DBT protein is shown to directly...

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Identifiers

PMID: 18666831
DOI: 10.1371/journal.pbio.0060183
PMCID: PMC2486307

Genes

DBT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating PER repressor through a DBT-directed phosphorylation switch.PMID 18666831Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

Drosophila DBT lacking protein kinase activity produces long-period and arrhythmic circadian behavioral and molecular rhythms.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.Semantic proximity Read ↗

Casein Kinase 1 dynamics underlie the PER2 circadian phosphoswitchSemantic proximity Read ↗

Casein kinase I: another cog in the circadian clockworks.Semantic proximity Read ↗

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Semantic proximity Read ↗

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.Semantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

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